同义词

3.4.25.1; LMPX; Macropain epsilon chain; MB1; Multicatalytic endopeptidase complex epsilon chain; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit MB1; Proteasome subunit X; X

UniProt ID

P28074

UniProt名字

PSB5_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

PSMB5

生物

Human

氨基酸序列

>lcl|BSEQ0037858|Proteasome subunit beta type-5 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE DGWIRVSSDNVADLHEKYSGSTP

目标基因序列

残基数

263

分子量

28480.01

理论 pI

8.68

一般功能

Threonine-type endopeptidase activity

具体功能

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).

跨膜区

GenBank 蛋白质 ID

558526

目标蛋白质序列

基因序列

>lcl|BSEQ0019273|Proteasome subunit beta type-5 (PSMB5) ATGGCTGGGGGCGCAGCGGATTGCAGCTTCTGGGAACGGCTGTTGGCTCGGCAATGTCGA ATCTATGAGCTTCGAAATAAGGAACGCATCTCTGTAGCAGCTGCCTCCAAACTGCTTGCC AACATGGTGTATCAGTACAAAGGCATGGGGCTGTCCATGGGCACCATGATCTGTGGCTGG GATAAGAGAGGCCCTGGCCTCTACTACGTGGACAGTGAAGGGAACCGGATTTCAGGGGCC ACCTTCTCTGTAGGTTCTGGCTCTGTGTATGCATATGGGGTCATGGATCGGGGCTATTCC TATGACCTGGAAGTGGAGCAGGCCTATGATCTGGCCCGTCGAGCCATCTACCAAGCCACC TACAGAGATGCCTACTCAGGAGGTGCAGTCAACCTCTACCACGTGCGGGAGGATGGCTGG ATCCGAGTCTCCAGTGACAATGTGGCTGATCTACATGAGAAGTATAGTGGCTCTACCCCC TGA

GenBank 基因 ID

D29011

基因卡 ID

Genatlas ID

PSMB5

HGNC ID

HGNC:9542

染色体位置

14

轨迹

14q11.2

信号区域

Pdb标识

4R3O; 4R67

KEGG ID

hsa:5693

细胞的位置

Cytoplasm