毒素T3DB ID

T3D2972

目标BioDB ID

BE0001009

目标名称

Cytochrome c

目标UniProt ID

P99999

作用机理

Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate.

参考文献

A2081 - Baydas G, Reiter RJ, Akbulut M, Tuzcu M, Tamer S: Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels. Neuroscience. 2005;135(3):879-86. (16213988) A2082 - Yang QH, Xu JN, Xu RK, Pang SF: Inhibitory effects of melatonin on the growth of pituitary prolactin-secreting tumor in rats. J Pineal Res. 2006 Apr;40(3):230-5. (16499559) A2085 - Lin AM, Fang SF, Chao PL, Yang CH: Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. J Pineal Res. 2007 Sep;43(2):163-71. (17645694) A2094 - Semak I, Naumova M, Korik E, Terekhovich V, Wortsman J, Slominski A: A novel metabolic pathway of melatonin: oxidation by cytochrome C. Biochemistry. 2005 Jul 5;44(26):9300-7. (15981996) A2095 - Han YX, Zhang SH, Wang XM, Wu JB: Inhibition of mitochondria responsible for the anti-apoptotic effects of melatonin during ischemia-reperfusion. J Zhejiang Univ Sci B. 2006 Feb;7(2):142-7. (16421971)

创建于

2009-07-22 22:37:13 UTC

更新于

2014-09-04 16:22:53 UTC

目标详情