毒素T3DB ID

T3D2972

目标BioDB ID

BE0001162

目标名称

Caspase-3

目标UniProt ID

P42574

作用机理

Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate.

参考文献

A2079 - Jang MH, Jung SB, Lee MH, Kim CJ, Oh YT, Kang I, Kim J, Kim EH: Melatonin attenuates amyloid beta25-35-induced apoptosis in mouse microglial BV2 cells. Neurosci Lett. 2005 May 20-27;380(1-2):26-31. Epub 2005 Jan 25. (15854745) A2081 - Baydas G, Reiter RJ, Akbulut M, Tuzcu M, Tamer S: Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels. Neuroscience. 2005;135(3):879-86. (16213988) A2086 - Juknat AA, Mendez Mdel V, Quaglino A, Fameli CI, Mena M, Kotler ML: Melatonin prevents hydrogen peroxide-induced Bax expression in cultured rat astrocytes. J Pineal Res. 2005 Mar;38(2):84-92. (15683462) A2087 - Wenzel U, Nickel A, Daniel H: Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products. Int J Cancer. 2005 Aug 20;116(2):236-42. (15800915) A2088 - Feng Z, Zhang JT: Long-term melatonin or 17beta-estradiol supplementation alleviates oxidative stress in ovariectomized adult rats. Free Radic Biol Med. 2005 Jul 15;39(2):195-204. Epub 2005 Mar 25. (15964511)

创建于

2009-07-22 22:37:13 UTC

更新于

2014-09-04 16:22:52 UTC

目标详情