同义词

3.4.22.56; Apopain; CASP-3; CPP-32; CPP32; Cysteine protease CPP32; Protein Yama; SCA-1; SREBP cleavage activity 1

UniProt ID

P42574

UniProt名字

CASP3_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

CASP3

生物

Human

氨基酸序列

>lcl|BSEQ0016333|Caspase-3 MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

目标基因序列

残基数

277

分子量

31607.58

理论 pI

6.51

一般功能

Phospholipase a2 activator activity

具体功能

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

跨膜区

GenBank 蛋白质 ID

561666

目标蛋白质序列

基因序列

>lcl|BSEQ0016334|Caspase-3 (CASP3) ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT GACATGGCGTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCA CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

GenBank 基因 ID

U13737

基因卡 ID

Genatlas ID

CASP3

HGNC ID

HGNC:1504

染色体位置

4

轨迹

4q34

信号区域

Pdb标识

1CP3; 1GFW; 1I3O; 1NME; 1NMQ; 1NMS; 1PAU; 1QX3; 1RE1; 1RHJ; 1RHK; 1RHM; 1RHQ; 1RHR; 1RHU; 2C1E; 2C2K; 2C2M; 2C2O; 2CDR; 2CJX; 2CJY; 2CNK; 2CNL; 2CNN; 2CNO; 2DKO; 2H5I; 2H5J; 2H65; 2J30; 2J31; 2J32; 2J33; 2XYG; 2XYH; 2XYP; 2XZD; 2XZT; 2Y0B; 3DEH; 3DEI; 3DEJ; 3DEK; 3EDQ; 3GJQ; 3GJR; 3GJS; 3GJT; 3H0E; 3ITN; 3KJF; 3PCX; 3PD0; 3PD1; 4DCJ; 4DCO; 4DCP; 4EHA; 4EHD; 4EHF; 4EHH; 4EHK; 4EHL; 4EHN; 4JJE; 4JQY; 4JQZ; 4JR0; 4PRY; 4PS0; 4QTX; 4QTY; 4QU0; 4QU5; 4QU8; 4QU9; 4QUA; 4QUB; 4QUD; 4QUE; 4QUG; 4QUH; 4QUI; 4QUJ; 4QUL

KEGG ID

hsa:836

细胞的位置

Cytoplasm