毒素T3DB ID

T3D0021

目标BioDB ID

BE0005003

目标名称

Plasma membrane calcium-transporting ATPase 2

目标UniProt ID

Q01814

作用机理

This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)

参考文献

T10 - Casarett LJ, Klaassen CD, and Watkins JB (2003). Casarett and Doull's essentials of toxicology. New York: McGraw-Hill/Medical Pub. Div.

创建于

2009-04-14 21:08:36 UTC

更新于

2014-09-04 16:08:10 UTC

目标详情