毒素T3DB ID

T3D0053

目标BioDB ID

BE0005176

目标名称

Lysine-specific demethylase 3A

目标UniProt ID

Q9Y4C1

作用机理

Nickel substitutes for iron in jmjC domain-containing histone demethylation proteins, inhibiting their demethylation activity. (A109)

参考文献

A109 - Chen H, Costa M: Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals. 2009 Feb;22(1):191-6. doi: 10.1007/s10534-008-9190-3. Epub 2008 Dec 19. (19096759) A8728 - Suzuki T, Miyata N: Lysine demethylases inhibitors. J Med Chem. 2011 Dec 22;54(24):8236-50. doi: 10.1021/jm201048w. Epub 2011 Oct 7. (21955276)

创建于

2009-05-16 00:38:29 UTC

更新于

2014-09-04 16:17:33 UTC

目标详情