同义词

1.14.11.-; JHDM2A; JmjC domain-containing histone demethylation protein 2A; JMJD1; JMJD1A; Jumonji domain-containing protein 1A; KIAA0742; TSGA

UniProt ID

Q9Y4C1

UniProt名字

KDM3A_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

KDM3A

生物

Human

氨基酸序列

>lcl|BSEQ0008940|Lysine-specific demethylase 3A MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKD LKVCVEFDGESWRKRRWIEVYSLLRRAFLVEHNLVLAERKSPEISERIVQWPAITYKPLL DKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIH VEVVHDNLVTCGNSARIGAVKRKSSENNGTLVSKQAKSCSEASPSMCPVQSVPTTVFKEI LLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEEISSCLNTKSEALRTK PDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQENRLESVPQALTGLPKECLPT KASSKAELEIANPPELQKHLEHAPSPSDVSNAPEVKAGVNSDSPNNCSGKKVEPSALACR SQNLKESSVKVDNESCCSRSNNKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIV AQLPKCRECRLDSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAI GLWLPLTKNVVGIDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVRE MCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWLKCVKSQIHEPENL MPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDLKQTSLAGEKP TLGAVLQQNPSVLEPAAVGGEAASKPAGSMKPACPASTSPLNWLADLTSGNVNKENKEKQ PTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGL KNTPKILDDIFASLVQNKTTSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNK SNWNVFRECWKQGQPVMVSGVHHKLNSELWKPESFRKEFGEQEVDLVNCRTNEIITGATV GDFWDGFEDVPNRLKNEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGK LNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQC EQEEEVLKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQEN PADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKV AEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSFGK P

目标基因序列

残基数

1321

分子量

147339.98

理论 pI

一般功能

Transcription regulatory region sequence-specific dna binding

具体功能

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

跨膜区

GenBank 蛋白质 ID

目标蛋白质序列

基因序列

>lcl|BSEQ0013520|Lysine-specific demethylase 3A (KDM3A) ATGGTGCTCACGCTCGGAGAAAGTTGGCCGGTATTGGTGGGGAGGAGGTTTCTCAGTCTG TCCGCAGCCGACGGCAGCGATGGCAGCCACGACAGCTGGGACGTGGAGCGCGTCGCCGAG TGGCCCTGGCTCTCCGGGACCATTCGAGCTGTTTCCCACACCGACGTTACCAAGAAGGAT CTGAAGGTGTGTGTGGAATTTGATGGGGAATCTTGGAGGAAAAGAAGATGGATAGAAGTC TACAGCCTTCTAAGGAGAGCATTTTTAGTAGAACATAATTTGGTTTTAGCTGAACGAAAG TCACCTGAAATTTCTGAACGAATTGTACAGTGGCCTGCAATAACGTACAAACCTCTGTTG GACAAAGCTGGTTTGGGATCCATAACTTCTGTTCGCTTTCTGGGAGATCAACAAAGAGTA TTTCTTTCTAAAGACCTTTTGAAGCCTATACAGGATGTAAACAGTCTTCGACTTTCTCTT ACGGATAATCAGATTGTCAGTAAAGAATTTCAAGCTTTGATTGTGAAGCATTTAGATGAA AGCCATCTTTTAAAAGGTGACAAAAACTTAGTTGGTTCAGAAGTAAAAATTTATAGCTTG GACCCATCTACTCAGTGGTTTTCAGCAACCGTTATAAATGGAAACCCAGCATCAAAAACT CTTCAAGTCAACTGTGAGGAGATTCCAGCACTGAAAATTGTTGATCCGTCACTGATTCAT GTTGAAGTTGTACACGATAACCTTGTGACATGTGGTAATTCTGCAAGAATTGGAGCTGTA AAACGCAAGTCTTCTGAGAATAATGGAACCCTGGTTTCCAAACAAGCAAAATCTTGCTCT GAGGCCTCTCCCAGTATGTGTCCTGTGCAGTCTGTACCTACAACAGTTTTTAAGGAGATA CTGCTTGGCTGTACTGCGGCAACTCCACCTAGTAAGGACCCAAGACAGCAAAGTACTCCC CAGGCTGCCAACTCTCCACCTAACCTTGGAGCAAAAATTCCTCAAGGATGTCATAAACAA AGTTTACCAGAGGAAATTTCTTCCTGTCTAAATACAAAGTCTGAAGCTCTGAGAACAAAA CCAGATGTCTGCAAAGCAGGGTTGCTCTCAAAGTCCTCTCAGATTGGAACTGGAGACTTG AAAATTCTGACTGAGCCAAAAGGCAGCTGTACTCAGCCTAAGACAAACACTGATCAGGAA AACAGATTGGAGTCTGTTCCACAAGCATTGACTGGCCTTCCTAAGGAGTGCTTACCTACA AAGGCTTCTTCTAAGGCAGAATTGGAAATTGCCAATCCTCCTGAACTGCAGAAGCACCTA GAACATGCACCTTCCCCATCGGATGTTTCAAATGCACCAGAAGTGAAAGCAGGTGTCAAT AGTGATAGCCCTAATAACTGTTCAGGAAAAAAGGTAGAACCTTCAGCTTTAGCTTGCCGA TCACAGAATTTAAAGGAATCTTCAGTAAAAGTAGATAATGAAAGCTGTTGTTCAAGAAGC AACAATAAAATCCAGAATGCCCCATCCAGGAAGTCGGTTTTGACAGACCCAGCTAAACTC AAAAAGCTGCAACAGAGTGGCGAGGCCTTCGTACAGGATGATTCTTGTGTGAACATCGTG GCACAGTTGCCTAAATGCCGAGAGTGTCGCTTGGACAGTCTCCGCAAGGATAAGGAGCAA CAGAAGGACTCACCTGTGTTTTGCCGCTTCTTTCACTTCAGGAGGTTACAATTCAACAAA CATGGTGTGTTGCGGGTAGAAGGCTTCTTAACACCAAACAAGTATGACAATGAAGCAATT GGCTTGTGGTTACCTTTAACCAAAAACGTTGTGGGGATTGATTTGGACACAGCAAAGTAC ATCTTGGCCAACATTGGAGACCACTTCTGTCAAATGGTGATTTCTGAAAAGGAAGCTATG TCAACTATTGAGCCACACAGACAGGTTGCTTGGAAGCGAGCTGTCAAAGGTGTTCGAGAA ATGTGTGATGTGTGCGACACCACCATCTTCAACCTGCACTGGGTGTGTCCTCGGTGTGGG TTTGGAGTATGTGTGGACTGCTACCGGATGAAGAGAAAGAATTGCCAACAGGGTGCTGCT TACAAGACTTTCTCTTGGCTAAAATGTGTGAAGAGTCAGATACATGAACCAGAGAACTTA ATGCCCACACAGATCATTCCTGGAAAAGCACTCTATGATGTTGGAGACATTGTTCATTCT GTAAGAGCGAAATGGGGAATAAAGGCAAACTGCCCTTGTTCAAACAGGCAATTCAAACTC TTTTCAAAGCCAGCCTCAAAGGAAGACCTAAAACAGACTTCTTTAGCTGGAGAAAAACCG ACTCTTGGTGCAGTGCTCCAGCAGAATCCCTCAGTGTTGGAGCCAGCAGCTGTGGGTGGG GAAGCAGCCTCCAAGCCAGCCGGCAGCATGAAGCCTGCCTGTCCAGCCAGCACATCTCCT CTAAACTGGCTGGCCGACCTAACCAGCGGGAATGTCAACAAGGAAAACAAGGAAAAACAA CCAACAATGCCAATTTTAAAGAATGAAATCAAATGCCTTCCACCCCTCCCACCTTTAAGC AAATCCAGCACAGTCCTCCATACGTTTAACAGCACAATTTTGACACCCGTAAGCAACAAC AATTCTGGTTTCCTCCGGAATCTCTTGAATTCTTCTACAGGAAAGACAGAAAATGGACTC AAGAATACACCAAAAATCCTTGATGACATCTTTGCCTCTTTGGTGCAAAATAAGACGACT TCTGATTTATCTAAGAGGCCTCAAGGACTAACCATCAAGCCCAGCATTCTGGGCTTTGAC ACTCCTCACTATTGGCTTTGTGATAATCGCTTGCTGTGCTTGCAAGACCCCAACAATAAG AGCAACTGGAATGTGTTTAGGGAGTGCTGGAAACAAGGGCAGCCAGTGATGGTGTCTGGA GTGCATCATAAATTGAACTCTGAACTTTGGAAACCTGAATCCTTCAGGAAAGAGTTTGGT GAGCAGGAAGTAGACCTAGTTAATTGTAGGACCAATGAAATCATCACAGGAGCCACAGTA GGAGACTTCTGGGATGGATTTGAAGATGTTCCAAATCGTTTGAAAAATGAAAAAGAACCA ATGGTGTTGAAACTTAAGGACTGGCCACCAGGAGAAGATTTTAGAGATATGATGCCTTCC AGGTTTGATGATCTGATGGCCAACATTCCACTGCCCGAGTACACAAGGCGAGATGGCAAA CTGAATTTGGCCTCTAGGCTGCCAAACTACTTTGTTCGGCCAGATCTGGGCCCCAAGATG TATAATGCTTATGGATTAATCACTCCTGAAGATCGGAAATATGGAACAACAAATCTTCAC TTAGATGTATCTGATGCAGCTAATGTCATGGTCTATGTGGGAATTCCCAAAGGACAGTGT GAGCAAGAAGAAGAAGTCCTTAAGACCATCCAAGATGGAGATTCTGACGAACTCACAATA AAGCGATTTATTGAAGGAAAAGAGAAGCCAGGAGCACTGTGGCACATATATGCTGCAAAG GACACGGAGAAGATAAGGGAATTTCTTAAAAAGGTATCAGAAGAGCAAGGTCAAGAAAAC CCAGCAGACCACGATCCTATTCATGATCAAAGCTGGTATTTAGACCGATCATTAAGAAAA CGTCTTCATCAAGAGTATGGAGTTCAAGGCTGGGCTATTGTACAGTTTCTTGGGGATGTG GTGTTTATCCCGGCAGGAGCTCCACATCAGGTTCATAACTTATATAGCTGCATCAAAGTG GCTGAAGATTTTGTTTCTCCAGAGCATGTTAAACACTGCTTCTGGCTTACTCAGGAATTC CGATATCTGTCACAGACTCATACCAATCACGAAGATAAATTACAGGTGAAGAATGTTATC TACCATGCAGTGAAAGATGCAGTTGCTATGCTGAAAGCCAGTGAATCCAGTTTTGGCAAA CCTTAA

GenBank 基因 ID

基因卡 ID

Genatlas ID

HGNC ID

HGNC:20815

染色体位置

2

轨迹

信号区域

Pdb标识

KEGG ID

hsa:55818

细胞的位置

Cytoplasm