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药物稳定性 348条(本栏目收费,不能显示细节,电话13136136841)
Dosage Level and Toxicity Considerations
202
Nonstoichiornetric Interactions with Water
204
Parenteral Solid Products
204
10.l. Lyophilized products
204
10.2. Stability of crystalline and amorphous lyophilates
205
10.3. The labeling dilemma of parenteral products
205
States of Matter: Crystallinity and Amorphicity
210
Solubilities of Polymorphs
213
Rates of Conversion in Moist Storage
215
Equilibrium Moisture Content of Solids and Hygroscopicity
215
Critical Moisture Content
219
Equilibrium Moisture Curves for Salt Hydrates
221
Moisture EquilibriumC urves of a Smooth Nature
224
Water Absorption “Isotherms” into Amorphates
226
Moisture Exchange Between. Dosage Form Ingredients
228
Equilibrium Moisture Contents for Macromolecules
231
Adsorption Isotherms of Silica
231
Preformulation’s Place in the Stability Function
238
Timing and Goals of Preformulation
239
Physicochemical Parameters
239
3.1. pK and ionizable substances
240
4.1, Use of salt formation to increase solubility
241
4.2. Nonionizable substances
242