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药物稳定性 348条(本栏目收费,不能显示细节,电话13136136841)
4. First-Order Reactions with More Than One End Product
27
4.1. Consecutive reactions of the first order
27
4.2. Parallel reactions
29
5.1. Steady-state situations
33
6. Pseudo-Zero-Order Reactions
34
7. The Arrhenius Equation
37
7.2. Nonisothermal kinetics
41
7.3. Kinetic mean temperature
42
8. Second-Order Reactions
46
8.1, Equal initial concentration. Reciprocal plots
52
8.2. Pseudo-first-order reactions
52
9. Complicated Hydrolysis Schemes
53
1.Oxidative Reactions
113
1.1. Oxidation mechanisms
114
1.2. Quantitative considerations in oxidations in two phases
115
1.3. Simple oxidation in solution in a closed system
117
1.4. Oxidation in an open system
120
1.5. Oxidative autocatalysis
122
2.More Complex Models
124
2.1. Stability prediction by fractional lives
126
4. Step 3: Stress and ACC ated Testing with Selected Formulations, Selection of Packaging Material, Up-Scaling Pilot Plant, Registration Batches
435
4.2. Application of the basic principles
436
4.3 Practical examples
443
5. Step 4: Accelerated and Long-Term Testing with Registration Batches up to Registration Application for Drug Substance and Drug Products
458