药物稳定性 348条(本栏目收费,不能显示细节,电话15274084725)
4. First-Order Reactions with More Than One End Product 27
4.1. Consecutive reactions of the first order 27
4.2. Parallel reactions 29
5.1. Steady-state situations 33
6. Pseudo-Zero-Order Reactions 34
7. The Arrhenius Equation 37
7.2. Nonisothermal kinetics 41
7.3. Kinetic mean temperature 42
8. Second-Order Reactions 46
8.1, Equal initial concentration. Reciprocal plots 52
8.2. Pseudo-first-order reactions 52
9. Complicated Hydrolysis Schemes 53
1.Oxidative Reactions 113
1.1. Oxidation mechanisms 114
1.2. Quantitative considerations in oxidations in two phases 115
1.3. Simple oxidation in solution in a closed system 117
1.4. Oxidation in an open system 120
1.5. Oxidative autocatalysis 122
2.More Complex Models 124
2.1. Stability prediction by fractional lives 126
4. Step 3: Stress and ACC ated Testing with Selected Formulations, Selection of Packaging Material, Up-Scaling Pilot Plant, Registration Batches 435
4.2. Application of the basic principles 436
4.3 Practical examples 443
5. Step 4: Accelerated and Long-Term Testing with Registration Batches up to Registration Application for Drug Substance and Drug Products 458