甲氨蝶呤,临床注释,变异和临床注释数据

甲氨蝶呤

临床注释ID

1451553326

药物名称(英)

methotrexate

变异单倍型

rs45445694

基因

C18orf56;TYMS

证据级别

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Metabolism/PK

表现型类别

代谢/PK

分数

-1.0

PMID计数

计数的证据

表现型

前体细胞淋巴细胞白血病-淋巴瘤

表现型(英)

Precursor Cell Lymphoblastic Leukemia-Lymphoma

最新日期

2021-10-21

URL

https://www.pharmgkb.org/clinicalAnnotation/1451553326

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
419	(CCGCGCCACTTGGCCTGCCTCCGTCCCG)3/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)3	The current evidence base suggests that there is no significant association between the rs45445694 (CCGCGCCACTTGGCCTGCCTCCGTCCCG)3/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)3 (3R/3R) genotype and concentrations of methotrexate in patients with acute lymphoblastic leukemia (ALL). However, conflicting evidence has been reported. This annotation only covers the pharmacokinetic relationship between rs45445694 and methotrexate and does not include evidence about clinical outcomes. Other genetic and clinical factors may also influence methotrexate concentrations.
418	(CCGCGCCACTTGGCCTGCCTCCGTCCCG)2/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)3	The current evidence base suggests that there is no significant association between the rs45445694 (CCGCGCCACTTGGCCTGCCTCCGTCCCG)2/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)3 (2R/3R) genotype and concentrations of methotrexate in patients with acute lymphoblastic leukemia (ALL). However, conflicting evidence has been reported. This annotation only covers the pharmacokinetic relationship between rs45445694 and methotrexate and does not include evidence about clinical outcomes. Other genetic and clinical factors may also influence methotrexate concentrations.
417	(CCGCGCCACTTGGCCTGCCTCCGTCCCG)2/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)2	The current evidence base suggests that there is no significant association between the rs45445694 (CCGCGCCACTTGGCCTGCCTCCGTCCCG)2/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)2 (2R/2R) genotype and concentrations of methotrexate in patients with acute lymphoblastic leukemia (ALL). However, conflicting evidence has been reported. This annotation only covers the pharmacokinetic relationship between rs45445694 and methotrexate and does not include evidence about clinical outcomes. Other genetic and clinical factors may also influence methotrexate concentrations.

临床证据

id	证据的ID	总结
14719	1451465044	Genotype (CCGCGCCACTTGGCCTGCCTCCGTCCCG)2/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)2 is not associated with concentrations of methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotypes (CCGCGCCACTTGGCCTGCCTCCGTCCCG)2/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)3 + (CCGCGCCACTTGGCCTGCCTCCGTCCCG)3/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)3.
30	1451552752	Genotype (CCGCGCCACTTGGCCTGCCTCCGTCCCG)3/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)3 is associated with increased steady-state concentration of methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotypes (CCGCGCCACTTGGCCTGCCTCCGTCCCG)2/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)2 + (CCGCGCCACTTGGCCTGCCTCCGTCCCG)2/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)3.

临床病史

id	类型	评论
55	Create	Created

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