The current evidence base suggests that there is no significant association between the rs45445694 (CCGCGCCACTTGGCCTGCCTCCGTCCCG)2/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)2 (2R/2R) genotype and concentrations of methotrexate in patients with acute lymphoblastic leukemia (ALL). However, conflicting evidence has been reported. This annotation only covers the pharmacokinetic relationship between rs45445694 and methotrexate and does not include evidence about clinical outcomes. Other genetic and clinical factors may also influence methotrexate concentrations.
基因型等位基因
(CCGCGCCACTTGGCCTGCCTCCGTCCCG)2/(CCGCGCCACTTGGCCTGCCTCCGTCCCG)2