id	等位基因	注释文本
760	GG	Patients with the rs1801086 GG genotype may have a decreased, but not absent, risk for malignant hyperthermia based on this variant when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with genotype AA, AG, CC, CG. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
759	CG	Patients with the rs1801086 CG genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with genotype GG. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
758	CC	Patients with the rs1801086 CC genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with genotype GG. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
757	AG	Patients with the rs1801086 AG genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with genotype GG. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
756	AA	Patients with the rs1801086 AA genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with genotype GG. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.

id	证据的ID	总结
3222	1449275206	Allele C is associated with increased risk of Malignant Hyperthermia when exposed to sevoflurane as compared to allele G.
3221	1447987329	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
3220	1447960710	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
3219	1447948045	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
3218	1447674350	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
3217	1447672542	Allele C is associated with increased risk of Malignant Hyperthermia as compared to allele G.
3216	1445400809	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
3215	1445400662	Genotypes AG + CG are associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
3214	1444697969	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
3213	1444697813	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
3212	1184511797	Allele A is associated with increased risk of Malignant Hyperthermia when exposed to halothane and succinylcholine as compared to allele G.
3211	PA166180457	Annotation of CPIC Guideline for desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane, succinylcholine and CACNA1S, RYR1

id	类型	评论
1130	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1129	Update	Drugs kept combined based on specifics of Malignant Hyperthermia diagnostics and CPIC guideline/EMHG inclusion.
1128	Update	Assigned LOE 1A since variant listed in recommendation of CPIC guideline
1127	Update	Added PMID 21804810
1126	Create

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