Patients with the rs1801086 GG genotype may have a decreased, but not absent, risk for malignant hyperthermia based on this variant when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with genotype AA, AG, CC, CG. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.