id	等位基因	注释文本
845	TT	Patients with the rs118192178 TT genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the CC genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
844	GG	Patients with the rs118192178 GG genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the CC genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
843	CT	Patients with the rs118192178 CT genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the CC genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
842	CG	Patients with the rs118192178 CG genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the CC genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
841	CC	Patients with the rs118192178 CC genotype may have a decreased, but not absent, risk for malignant hyperthermia based on this variant when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the CT, CG, GG or TT genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.

id	证据的ID	总结
126	1449157821	Allele T is associated with increased risk of Malignant Hyperthermia when exposed to rocuronium and sevoflurane as compared to allele C.
125	1447952930	Genotype CT is associated with increased risk of Malignant Hyperthermia as compared to genotype CC.
124	1447673056	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
123	1447645111	Allele G is associated with increased risk of Malignant Hyperthermia as compared to allele C.
122	1447644525	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
121	1447641258	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
120	1447640254	Allele T is associated with increased risk of Malignant Hyperthermia when exposed to sevoflurane as compared to allele C.
119	PA166180457	Annotation of CPIC Guideline for desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane, succinylcholine and CACNA1S, RYR1

id	类型	评论
1265	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1264	Update	Drugs kept combined based on specifics of Malignant Hyperthermia diagnostics and CPIC guideline/EMHG inclusion.
1263	Update	Assigned LOE 1A since variant listed in recommendation of CPIC guideline
1262	Update	Added PMID 27918309
1261	Create

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