Patients with the rs118192178 CC genotype may have a decreased, but not absent, risk for malignant hyperthermia based on this variant when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the CT, CG, GG or TT genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.