干扰素；聚乙二醇干扰素 alfa-2a；聚乙二醇干扰素 alfa-2b；利巴韦林,临床注释-2,变异和临床注释数据

干扰素；聚乙二醇干扰素 alfa-2a；聚乙二醇干扰素 alfa-2b；利巴韦林

临床注释ID

981239773

药物名称(英)

interferons;peginterferon alfa-2a;peginterferon alfa-2b;ribavirin

变异单倍型

rs8099917

基因

IFNL3

证据级别

水平覆盖

Yes: Assigned level 1B because variant is not part of the CPIC guideline recommendation, this variant is in high LD with CPIC variant rs12979860.

水平修饰符

表现型类别(英)

Efficacy

表现型类别

功效

分数

93.75

PMID计数

计数的证据

表现型

丙型肝炎，慢性

表现型(英)

Hepatitis C, Chronic

最新日期

2021/3/29 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/981239773

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
829	TT	Patients with the rs8099917 TT genotype and chronic hepatitis C infection may have increased response (higher SVR) to peginterferon alfa and ribavirin therapy as compared to patients with the GG or GT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence response to peginterferon alfa and ribavirin therapy. Please note that this SNP has been found to be in high LD with rs12979860 which is also associated with response to pegIFN-alpha/ribavirin.
828	GT	Patients with the rs8099917 GT genotype and chronic hepatitis C infection may have decreased response (lower SVR) to peginterferon alfa and ribavirin therapy as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence response to peginterferon alfa and ribavirin therapy. Please note that this SNP has been found to be in high LD with rs12979860 which is also associated with response to pegIFN-alpha/ribavirin.
827	GG	Patients with the rs8099917 GG genotype and chronic hepatitis C infection may have decreased response (lower SVR) to peginterferon alfa and ribavirin therapy as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence response to peginterferon alfa and ribavirin therapy. Please note that this SNP has been found to be in high LD with rs12979860 which is also associated with response to pegIFN-alpha/ribavirin.

临床证据

id	证据的ID	总结
890	1444705262	Genotypes GG + GT is associated with decreased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C.
889	1444705254	Genotypes GG + GT is associated with decreased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotype TT.
888	1444705147	Genotype TT is associated with increased response to interferon alfa-n1, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
887	1444705133	Genotype TT is associated with increased response to interferon alfa-n1, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
886	1444705115	Genotype TT is associated with increased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Hepatitis C, HIV Infections and HIV Infections as compared to genotypes GG + GT.
885	1444668556	Genotype TT is associated with increased response to interferon alfa-2a, recombinant, interferon alfa-2b, recombinant and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
884	1444668499	Genotype TT is associated with increased response to interferon alfa-2a, recombinant, interferon alfa-2b, recombinant and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
883	1184136365	Genotype TT is associated with increased rapid virological response (rvr) and sustained virological response (svr) when treated with peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
882	1184136190	Genotypes GG + GT are associated with increased risk of treatment failure when treated with peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotype TT.
881	827815352	Genotype TT is associated with increased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
880	769248378	Allele T is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to allele G.
879	982031621	Genotype TT is not associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotypes GG + GT.
878	981934519	Genotype TT is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotypes GG + GT.
877	981501236	Allele T is associated with increased response (SVR and RVR) in HCV-HIV coinfected patients when treated with peginterferon alfa-2a, peginterferon alfa-2b and ribavirin as compared to allele G.
876	981483548	Genotype TT is associated with increased response to peginterferon alfa-2b in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
875	981483541	Genotype TT is associated with increased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
874	981483529	Genotype TT is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
873	981481567	Genotype TT is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
872	981481560	Genotype TT is associated with increased response to peginterferon alfa-2a and ribavirin in people with Hepatitis C, Chronic as compared to genotype GT.
871	981481554	Genotype TT is associated with increased response to peginterferon alfa-2a and ribavirin in people with Hepatitis C, Chronic as compared to genotype GT.
870	981481540	Genotype TT is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in Hepatitis C, Chronic as compared to genotypes GG + GT.
869	981479690	Genotype TT is not associated with resistance to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
868	981479677	Genotype TT is associated with increased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
867	981479639	Genotypes GG + GT are associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotype TT.
866	981479632	Genotype TT is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
865	981419944	Genotype TT is associated with sustained virological response (SVR) and changes in viral load after 4 weeks of treatment when treated with peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
864	981419932	Genotype TT is associated with faster viral elimination (early virologic response) at week 2 or week 4 of antiviral treatment in HCV genotype 3 patients when treated with peginterferon alfa-2a and ribavirin in people with Hepatitis C as compared to genotypes GG + GT.
863	981419920	Genotype TT is not associated with sustained virological response (SVR) rate in HCV genotype 3 patients when treated with peginterferon alfa-2a and ribavirin in people with Hepatitis C as compared to genotypes GG + GT.
862	981419798	Genotype TT is not associated with sustained virological response (SVR) to PEG-IFN/ribavirin therapy at 4 weeks in HCV genotype 3 patients when treated with peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotypes GG + GT.
861	981419788	Genotype TT is associated with rapid viral response (RVR) to PEG-IFN/ribavirin therapy at 4 weeks in HCV genotype 3 patients when treated with peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotypes GG + GT.
860	981352203	Genotype TT is not associated with increased response (SVR) to interferon monotherapy in HCV genotype 2 patients when treated with interferons in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
859	981352194	Genotype TT is associated with increased response (SVR) to interferon monotherapy in HCV genotype 1 patients when treated with interferons in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
858	981352176	Genotype TT is not associated with increased response (SVR) in HCV genotype 2 patients when treated with peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
857	981352170	Genotype TT is associated with increased response (SVR) in HCV genotype 1 patients when treated with peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
856	981344120	Genotype TT is not associated with virological response (early, end-of-treatment and sustained virological response) in HCV-5 infected chronic hepatitis C patients when treated with peginterferon alfa-2a, peginterferon alfa-2b and ribavirin as compared to genotypes GG + GT.
855	981240106	Genotype GG is associated with lack of treatment response when treated with peginterferon alfa-2a and ribavirin in people with Hepatitis C as compared to genotypes GT + TT.
468	1448995614	Allele G is associated with decreased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to allele T.
467	1447951892	Genotype GG is associated with increased response to interferons and ribavirin in people with Hepatitis C as compared to genotypes GT + TT.
466	1447948089	Genotype TT is not associated with increased sustained virological response (svr) when treated with peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
465	1447948073	Genotype TT is associated with increased rapid virological response (rvr) when treated with peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
464	1447682270	Allele T is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in children with Hepatitis C as compared to allele G.
463	1447676959	Genotype TT is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotypes GG + GT.
462	1445296808	Genotypes GG + GT is associated with decreased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotype TT.
461	1445296333	Genotype TT is associated with increased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotypes GG + GT.
460	1444843741	Genotype TT is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
459	1444843578	Genotype TT is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotype GT.
458	1444843486	Genotype TT is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic and Hepatitis C, Chronic as compared to genotypes GG + GT.
457	1444707052	Genotype TT is associated with increased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotype GT.
456	1444707045	Genotype TT is associated with increased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotypes GG + GT.
455	1444706848	Genotype TT is associated with increased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotypes GG + GT.
454	1444706671	Genotype TT is associated with increased response to peginterferon alfa-2b in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
453	1444706377	Genotype TT is not associated with response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
452	1444705817	Genotype TT is associated with increased response to peginterferon alfa-2a and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GT + TT.
451	1444705593	Genotype GG is associated with decreased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotype TT.
450	1444705585	Genotype GT is associated with decreased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotype TT.
449	1444705578	Allele G is associated with decreased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to allele T.
448	1444705520	Genotypes GG + GT is associated with decreased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotype TT.
447	1444705313	Genotype TT is associated with increased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes GG + GT.
446	1444705281	Genotype TT is associated with increased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotypes GG + GT.

临床病史

id	类型	评论
1234	Update	Corrected LOE
1233	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1232	Update	override to level 1B as it's not a variant in CPIC recommendation table.
1231	Update	updated text
1230	Update	Added PMID 21931540 to evidence

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