Patients with the rs8099917 GT genotype and chronic hepatitis C infection may have decreased response (lower SVR) to peginterferon alfa and ribavirin therapy as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence response to peginterferon alfa and ribavirin therapy. Please note that this SNP has been found to be in high LD with rs12979860 which is also associated with response to pegIFN-alpha/ribavirin.