匹伐他汀,临床注释-2,变异和临床注释数据

id	等位基因	注释文本
1009	*37	The SLCO1B137 allele (defined as consisting of rs2306283) is assigned as a normal function allele by CPIC. Patients carrying SLCO1B137 allele in combination with another normal function allele may have decreased exposure to pitavastatin as compared to patients with a no function allele in combination with a normal or increased function allele or with two no function alleles. Other genetic or clinical factors may also affect a patient's exposure to pitavastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and pitavastatin and does not include evidence about clinical outcomes.
1008	*15	The SLCO1B115 allele (defined as consisting of both rs4149056 and rs2306283) is assigned as a no function allele by CPIC. Patients carrying SLCO1B115 allele in combination with a normal, no, or increased function allele may have increased exposure to pitavastatin as compared to patients with two normal function alleles. Other genetic or clinical factors may also affect a patient's exposure to pitavastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and pitavastatin and does not include evidence about clinical outcomes.
1007	*5	The SLCO1B15 allele (defined as consisting of rs4149056) is assigned as a no function allele by CPIC. Patients carrying SLCO1B15 allele in combination with a normal, no, or increased function allele may have increased exposure to pitavastatin as compared to patients with two normal function alleles. Other genetic or clinical factors may also affect a patient's exposure to pitavastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and pitavastatin and does not include evidence about clinical outcomes.
1006	*1	The SLCO1B11 allele is assigned as a normal function allele by CPIC. Patients carrying SLCO1B11 allele in combination with another normal function allele may have decreased exposure to pitavastatin as compared to patients with a no function allele in combination with a normal or increased function allele or with two no function alleles. Other genetic or clinical factors may also affect a patient's exposure to pitavastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and pitavastatin and does not include evidence about clinical outcomes.

等位基因

注释文本

The SLCO1B1*37 allele (defined as consisting of rs2306283) is assigned as a normal function allele by CPIC. Patients carrying SLCO1B1*37 allele in combination with another normal function allele may have decreased exposure to pitavastatin as compared to patients with a no function allele in combination with a normal or increased function allele or with two no function alleles. Other genetic or clinical factors may also affect a patient's exposure to pitavastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and pitavastatin and does not include evidence about clinical outcomes.

1008

*15

The SLCO1B1*15 allele (defined as consisting of both rs4149056 and rs2306283) is assigned as a no function allele by CPIC. Patients carrying SLCO1B1*15 allele in combination with a normal, no, or increased function allele may have increased exposure to pitavastatin as compared to patients with two normal function alleles. Other genetic or clinical factors may also affect a patient's exposure to pitavastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and pitavastatin and does not include evidence about clinical outcomes.

1007

The SLCO1B1*5 allele (defined as consisting of rs4149056) is assigned as a no function allele by CPIC. Patients carrying SLCO1B1*5 allele in combination with a normal, no, or increased function allele may have increased exposure to pitavastatin as compared to patients with two normal function alleles. Other genetic or clinical factors may also affect a patient's exposure to pitavastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and pitavastatin and does not include evidence about clinical outcomes.

1006

The SLCO1B1*1 allele is assigned as a normal function allele by CPIC. Patients carrying SLCO1B1*1 allele in combination with another normal function allele may have decreased exposure to pitavastatin as compared to patients with a no function allele in combination with a normal or increased function allele or with two no function alleles. Other genetic or clinical factors may also affect a patient's exposure to pitavastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and pitavastatin and does not include evidence about clinical outcomes.

id	证据的ID	总结
1876	1451674400	SLCO1B1 15/15 + 15/37 are associated with increased concentrations of pitavastatin in healthy individuals as compared to SLCO1B1 37/37.
1875	1451451080	SLCO1B1 15/15 is associated with increased concentrations of pitavastatin or pravastatin in healthy individuals as compared to SLCO1B1 1/1.
1874	1451226403	SLCO1B1 15/15 is associated with increased concentrations of pitavastatin in healthy individuals as compared to SLCO1B1 1/1 + 1/15.
1873	1450814783	SLCO1B1 15 is associated with increased exposure to pitavastatin in healthy individuals as compared to SLCO1B1 1/*1.
1872	1451674520	Genotypes CC + CT are associated with increased concentrations of pitavastatin in healthy individuals as compared to genotype TT.
1871	PA166262261	Annotation of CPIC Guideline for pitavastatin and SLCO1B1

证据的ID

总结

1876

1451674400

SLCO1B1 *15/*15 + *15/*37 are associated with increased concentrations of pitavastatin in healthy individuals as compared to SLCO1B1 *37/*37.

1875

1451451080

SLCO1B1 *15/*15 is associated with increased concentrations of pitavastatin or pravastatin in healthy individuals as compared to SLCO1B1 *1/*1.

1874

1451226403

SLCO1B1 *15/*15 is associated with increased concentrations of pitavastatin in healthy individuals as compared to SLCO1B1 *1/*1 + *1/*15.

1873

1450814783

SLCO1B1 *15 is associated with increased exposure to pitavastatin in healthy individuals as compared to SLCO1B1 *1/*1.

1872

1451674520

Genotypes CC + CT are associated with increased concentrations of pitavastatin in healthy individuals as compared to genotype TT.

1871

PA166262261

Annotation of CPIC Guideline for pitavastatin and SLCO1B1

id	类型	评论
761	Note	Second curator check
760	Update	added guideline as evidence, updated text
759	Update	CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
758	Create	Created

类型

added guideline as evidence, updated text

759

Update

CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.

758

Create