氟尿嘧啶,临床注释-2,变异和临床注释数据

氟尿嘧啶

临床注释ID

981201981

药物名称(英)

fluorouracil

变异单倍型

rs1801265

基因

DPYD

证据级别

1A

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Toxicity

表现型类别

毒性

分数

93.25

PMID计数

17

计数的证据

19

表现型

肿瘤

表现型(英)

Neoplasms

最新日期

2021/3/24 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/981201981

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
939	GG	Both variants of rs1801265 are assigned normal function by CPIC. Patients with the GG genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AG or AA genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
938	AG	Both variants of rs1801265 are assigned normal function by CPIC. Patients with the AG genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AA or GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
937	AA	Both variants of rs1801265 are assigned normal function by CPIC. Patients with the AA genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AG or GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

临床证据

id	证据的ID	总结
2820	1449732144	Genotypes AA + AG is associated with increased risk of Diarrhea when treated with capecitabine or fluorouracil in people with Gastrointestinal Neoplasms as compared to genotype GG.
2819	1449731947	Genotypes AA + AG is associated with decreased Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype GG.
2818	1449162062	Genotypes AG + GG is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colonic Neoplasms as compared to genotype AA.
2817	1448262652	Allele G is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
2816	1448126278	Allele G is not associated with severity of Drug Toxicity when treated with fluorouracil in people with Colonic Neoplasms and Colorectal Neoplasms as compared to allele A.
2815	1450954546	Allele G is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele A.
2814	1450954100	Allele G is not associated with severity of Drug Toxicity when treated with fluorouracil.
2813	1450953284	Allele G is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to allele A.
2812	1450952670	Allele G is associated with increased likelihood of Drug Toxicity when treated with fluorouracil in people with Neoplasms, Breast Neoplasms, Colonic Neoplasms, Rectal Neoplasms or Stomach Neoplasms.
2811	1450951420	Genotype AG is associated with increased risk of Cardiomyopathies when treated with fluorouracil in people with Rectal Neoplasms.
2810	1450951020	Allele G is not associated with severity of Drug Toxicity when treated with fluorouracil in people with Head and Neck Neoplasms as compared to allele A.
2809	827892947	Genotype AG is not associated with Drug Toxicity when treated with fluorouracil in people with Neoplasms as compared to genotype AA.
2808	827892796	Genotypes AG + GG are not associated with increased risk of Drug Toxicity when treated with fluorouracil in people with Neoplasms as compared to genotype AA.
2807	981390734	Genotypes AG + GG are associated with decreased likelihood of overall gastrointestinal toxicity when treated with fluorouracil in people with Neoplasms as compared to genotype AA.
2806	1447945354	Genotypes AG + GG is associated with increased Infection, nephrotoxicity and Toxic liver disease when treated with fluorouracil in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype AA.
2805	1447676563	Allele G is associated with increased risk of hand-foot syndrome, Photophobia and Unspecified conjunctivitis when treated with fluorouracil in women with Rectal Neoplasms.
2804	1451287140	Genotype AG is not associated with increased likelihood of Leukopenia when treated with fluorouracil in people with Neoplasms as compared to genotype AA.
2803	769169883	Genotype AG is associated with increased likelihood of Nausea and Vomiting when treated with fluorouracil in people with Neoplasms as compared to genotype AA.
2802	PA166122686	Annotation of CPIC Guideline for fluorouracil and DPYD

临床病史

id	类型	评论
656	Update	CA score added as part of scoring system release. LOE assigned following curator review.
655	Update	Attached CPIC guideline and removed override. Added CPIC function and modified text.
654	Update	CA for ADR and fluorouracil (score -4.75); level 1A since included in CPIC guideline as normal function variant
653	Update	updated text
652	Update	updated content from *9A to rs1801265
651	Update	removed VA for PMID: 11988088
650	Update	Minor rewording of AG phenotype description
649	Update

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