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氟伐他汀
临床注释ID
1451678620
药物名称(英)
fluvastatin
变异单倍型
SLCO1B1*1, SLCO1B1*5, SLCO1B1*15
基因
SLCO1B1
证据级别
1A
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Metabolism/PK
表现型类别
代谢/PK
分数
101.625
PMID计数
4
计数的证据
6
表现型
表现型(英)
最新日期
2022/2/10 0:00:00
URL
https://www.pharmgkb.org/clinicalAnnotation/1451678620
专业人口(英)
专业人口
临床等位基因
id等位基因注释文本
1165 *15 The SLCO1B1*15 allele (defined as consisting of both rs4149056 and rs2306283) is assigned as a no function allele by CPIC. Patients carrying SLCO1B1*15 allele in combination with a normal, no, or increased function allele may have increased fluvastatin concentration when treated with fluvastatin as compared to patients with two normal function alleles. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence the metabolism of fluvastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and fluvastatin and does not include evidence about clinical outcomes.
1164 *5 The SLCO1B1*5 allele (defined as consisting of rs4149056) is assigned as a no function allele by CPIC. Patients carrying SLCO1B1*5 allele in combination with a normal, no, or increased function allele may have increased fluvastatin concentration when treated with fluvastatin as compared to patients with two normal function alleles. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence the metabolism of fluvastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and fluvastatin and does not include evidence about clinical outcomes.
1163 *1 The SLCO1B1*1 allele is assigned as a normal function allele by CPIC. Patients carrying SLCO1B1*1 allele in combination with another normal function allele may have decreased fluvastatin concentration when treated with fluvastatin as compared to patients with a no function allele in combination with a normal or increased function allele or with two no function alleles. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence the metabolism of fluvastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and fluvastatin and does not include evidence about clinical outcomes.
临床证据
id证据的ID总结
4485 1451451102 SLCO1B1 *15/*15 is not associated with increased concentrations of fluvastatin in healthy individuals as compared to SLCO1B1 *1/*1.
4484 1451226441 SLCO1B1 *15/*15 is not associated with increased concentrations of fluvastatin in healthy individuals as compared to SLCO1B1 *1/*1 + *1/*15.
4483 1450823509 Allele C is associated with increased concentrations of fluvastatin in healthy individuals as compared to allele T.
4482 827827170 Genotype CC is not associated with increased mean peak concentration in plasma and area under the plasma concentration when exposed to fluvastatin in men as compared to genotypes CT + TT.
4481 1450823491 Allele T is associated with increased concentrations of fluvastatin in healthy individuals as compared to allele C.
4480 PA166262341 Annotation of CPIC Guideline for fluvastatin and CYP2C9, SLCO1B1
临床病史
id类型评论
1658 Create Created

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