The SLCO1B1*1 allele is assigned as a normal function allele by CPIC. Patients carrying SLCO1B1*1 allele in combination with another normal function allele may have decreased fluvastatin concentration when treated with fluvastatin as compared to patients with a no function allele in combination with a normal or increased function allele or with two no function alleles. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence the metabolism of fluvastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and fluvastatin and does not include evidence about clinical outcomes.