TARGETID

T98269

FORMERID

TTDR00434

UNIPROID

CASP1_HUMAN

TARGNAME

Caspase-1 (CASP1)

GENENAME

CASP1

TARGTYPE

Clinical trial target

SYNONYMS

P45; Interleukin-1 beta-converting enzyme; Interleukin-1 beta converting enzyme; Interleukin-1 beta convertase; IL1BCE; IL1BC; IL-1BC; IL-1 beta-converting enzyme; IL-1 beta converting enzyme; ICE; CASP-1

FUNCTION

Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.22.36

SEQUENCE

MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

DRUGINFO

AC-201

DRUGINFO

Belnacasan

DRUGINFO

Nivocasan

DRUGINFO

PRALNACASAN

DRUGINFO

Ac-YVAD-cmk

DRUGINFO

Ac-YVAD-FMK

DRUGINFO

L-709049

DRUGINFO

SDZ-224-015

DRUGINFO

VE-16084