TARGETID

T97766

FORMERID

TTDI02423

UNIPROID

CD47_HUMAN

TARGNAME

Leukocyte surface antigen CD47 (CD47)

GENENAME

CD47

TARGTYPE

Clinical trial target

SYNONYMS

Protein MER6; MER6; Integrinassociated protein; Integrin-associated protein; IAP; Antigenic surface determinant protein OA3

FUNCTION

Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins.

PDBSTRUC

5TZU; 5TZT; 5TZ2; 5IWL; 4KJY

BIOCLASS

Osteoclast fusion complex

SEQUENCE

MWPLVAALLLGSACCGSAQLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNENILIVIFPIFAILLFWGQFGIKTLKYRSGGMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLLISGLSILALAQLLGLVYMKFVASNQKTIQPPRKAVEEPLNAFKESKGMMNDE

DRUGINFO

Hu5F9-G4

DRUGINFO

ALX148

DRUGINFO

AO-176

DRUGINFO

DSP-107

DRUGINFO

CC-90002

DRUGINFO

IBI188

DRUGINFO

IMC-002

DRUGINFO

SL-172154

DRUGINFO

TG-1801