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靶点信息17(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Mannose-6-phosphate receptor (M6PR)
TARGTYPE
Successful target
SYNONYMS
MPRD; MPR46; MPR 46; Cation-dependent mannose-6-phosphate receptor; CDMan-6-P receptor; CD-MPR; CD Man-6-P receptor; 46kDa mannose 6-phosphate receptor; 46 kDa mannose 6-phosphate receptor
FUNCTION
Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes.
BIOCLASS
Mannose 6-phosphate receptor
SEQUENCE
MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
DRUGINFO
Alglucosidase alfa
DRUGINFO
1-3 Sugar Ring of Pentamannosyl 6-Phosphate
DRUGINFO
Alpha-D-Mannose-6-Phosphate
KEGGPATH
hsa04142:Lysosome
KEGGPATH
hsa04145:Phagosome
REACPATH
R-HSA-432720:Lysosome Vesicle Biogenesis
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Mannose-6-phosphate receptor (M6PR) |
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