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靶点信息15(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
MAPK signal-integrating kinase 1 (MKNK1)
TARGTYPE
Clinical trial target
SYNONYMS
Mnk1; MAP kinase signal-integrating kinase 1
FUNCTION
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
PDBSTRUC
5WVD; 2Y9Q; 2HW6
BIOCLASS
Protein kinase superfamily. CAMK Ser/Thr protein kinase family
SEQUENCE
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
KEGGPATH
hsa04010:MAPK signaling pathway
KEGGPATH
hsa04066:HIF-1 signaling pathway
KEGGPATH
hsa04910:Insulin signaling pathway
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04010 |
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| hsa04066 |
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| hsa04910 |
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目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| MAPK signal-integrating kinase 1 (MKNK1) |
|