TARGETID

T96760

FORMERID

TTDI02078

UNIPROID

GDF5_HUMAN

TARGNAME

Growth/differentiation factor 5 (GDF-5)

GENENAME

GDF5

TARGTYPE

Clinical trial target

SYNONYMS

Radotermin; Lipopolysaccharide-associated protein 4; LPS-associated protein 4; LAP-4; Cartilagederived morphogenetic protein 1; Cartilage-derived morphogenetic protein 1; CDMP1; CDMP-1; Bone morphogenetic protein 14; BMP14; BMP-14

FUNCTION

During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Growth factor involved in bone and cartilage formation.

PDBSTRUC

5HK5; 3QB4; 3EVS; 2BHK; 1WAQ

BIOCLASS

Growth factor

SEQUENCE

MRLPKLLTFLLWYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPLARNVFRPGGHSYGGGATNANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR

DRUGINFO

RhGDF-5

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04350:TGF-beta signaling pathway

KEGGPATH

hsa04390:Hippo signaling pathway

WIKIPATH

WP2666:Elastic fibre formation

WIKIPATH

WP2848:Differentiation Pathway

REACPATH

R-HSA-2129379:Molecules associated with elastic fibres

NET_PATH

NetPath_13:IL1 Signaling Pathway

NET_PATH

NetPath_7:TGF_beta_Receptor Signaling Pathway