TARGETID

T92750

FORMERID

TTDI02355

UNIPROID

CFAI_HUMAN

TARGNAME

Complement factor I (CFI)

GENENAME

CFI

TARGTYPE

Literature-reported target

SYNONYMS

IF; Complement factor I light chain; C3B/C4B inactivator

FUNCTION

Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways.

PDBSTRUC

5O32; 2XRC

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.21.45

SEQUENCE

MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCVCKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTECLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVTQEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV

DRUGINFO

TP-20

KEGGPATH

hsa04610:Complement and coagulation cascades

KEGGPATH

hsa05150:Staphylococcus aureus infection

WIKIPATH

WP1798:Complement cascade

WIKIPATH

WP2806:Human Complement System

WIKIPATH

WP558:Complement and Coagulation Cascades

REACPATH

R-HSA-977606:Regulation of Complement cascade