靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T92609

FORMERID

TTDC00292

UNIPROID

ADA1A_HUMAN

TARGNAME

Adrenergic receptor alpha-1A (ADRA1A)

GENENAME

ADRA1A

TARGTYPE

Successful target

SYNONYMS

Alpha-adrenergic receptor 1c; Alpha-1C adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1A adrenergic receptor; Alpha adrenergic receptor 1c; Alpha 1A-adrenoreceptor; Alpha 1A-adrenoceptor; ADRA1C

FUNCTION

Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV

DRUGINFO

NAFTOPIDIL

DRUGINFO

SILODOSIN

DRUGINFO

Tamsulosin

DRUGINFO

Xatral

DRUGINFO

Besipirdine

DRUGINFO

Dutasteride + tamsulosin

DRUGINFO

MEDETOMIDINE

DRUGINFO

PMID30124346-Compound-LDT66

Patented

DRUGINFO

D0EO8F

PMID30124346-Compound-LDT8

Patented

DRUGINFO

D03ITI

Sunepitron

Discontinued in Phase 3

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04152	AMPK signaling pathway
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04270	Vascular smooth muscle contraction
hsa04970	Salivary secretion

目标的 Wiki 路径数据

标题	内容
WP58	Monoamine GPCRs
WP536	Calcium Regulation in the Cardiac Cell
WP455	GPCRs, Class A Rhodopsin-like
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP2197	Endothelin Pathways
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling
WP1403	AMPK Signaling

目标的蛋白质ID

标题	内容
TARGETID	T92609
UNIPROID	ADA1A_HUMAN
TARGNAME	Adrenergic receptor alpha-1A (ADRA1A)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Adrenergic receptor alpha-1A (ADRA1A)	MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV

标题

内容

Adrenergic receptor alpha-1A (ADRA1A)

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