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靶点信息
TARGNAME
Orexin receptor (HCRTR)
TARGTYPE
Patented-recorded target
SYNONYMS
Hypocretin receptor
FUNCTION
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.
DRUGINFO
1,2-diamino cyclopentane-based derivative 28