TARGETID

T86399

FORMERID

TTDI02030

UNIPROID

BRD2_HUMAN

TARGNAME

Bromodomain-containing protein 2 (BRD2)

GENENAME

BRD2

TARGTYPE

Clinical trial target

SYNONYMS

Really interesting new gene 3 protein; RING3; O27.1.1; KIAA9001

FUNCTION

Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. May play a role in spermatogenesis or folliculogenesis.

PDBSTRUC

6MOA; 6MO9; 6MO8; 6MO7; 6FFG

BIOCLASS

Bromodomain

SEQUENCE

MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG

DRUGINFO

OTX-015

DRUGINFO

ABBV-744

DRUGINFO

PMID26924192-Compound-102

DRUGINFO

PMID26924192-Compound-103

DRUGINFO

PMID26924192-Compound-104

DRUGINFO

PMID26924192-Compound-105

DRUGINFO

PMID26924192-Compound-106

DRUGINFO

Pyrrolo-pyrrolone derivative 1

DRUGINFO

BIC1