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靶点信息21(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
G-protein coupled bile acid receptor 1 (GPBAR1)
TARGTYPE
Clinical trial target
SYNONYMS
hGPCR19; hBG37; TGR5; Membrane-type receptor for bile acids; M-BAR; G-protein coupled receptor GPCR19; BG37
FUNCTION
Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Receptor for bile acid.
SEQUENCE
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
DRUGINFO
Sodium taurocholate
DRUGINFO
PMID29649907-Compound-8
DRUGINFO
PMID29649907-Compound-INT767
WIKIPATH
WP1824:GPCR downstream signaling
WIKIPATH
WP1825:GPCR ligand binding
REACPATH
R-HSA-373076:Class A/1 (Rhodopsin-like receptors)
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| G-protein coupled bile acid receptor 1 (GPBAR1) |
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