TARGETID

T86115

FORMERID

TTDC00328

UNIPROID

APOC3_HUMAN

TARGNAME

ApoC-III messenger RNA (APOC3 mRNA)

GENENAME

APOC3

SYNONYMS

Apolipoprotein CIII (mRNA); Apolipoprotein C3 (mRNA); Apolipoprotein C-III (mRNA); ApoC-III (mRNA); Apo-CIII (mRNA)

FUNCTION

Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners. Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma.

PDBSTRUC

2JQ3

BIOCLASS

mRNA target

SEQUENCE

MQPRVLLVVALLALLASARASEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA

DRUGINFO

Volanesorsen

DRUGINFO

ISIS-APOCIII

KEGGPATH

hsa03320:PPAR signaling pathway

WIKIPATH

WP2764:Lipid digestion, mobilization, and transport

WIKIPATH

WP2776:Visual phototransduction

WIKIPATH

WP2878:PPAR Alpha Pathway

WIKIPATH

WP430:Statin Pathway

REACPATH

R-HSA-174800:Chylomicron-mediated lipid transport

REACPATH

R-HSA-194223:HDL-mediated lipid transport

REACPATH

R-HSA-975634:Retinoid metabolism and transport