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靶点信息61(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Prostaglandin E2 receptor EP3 (PTGER3)
TARGTYPE
Clinical trial target
SYNONYMS
Prostanoid EP3 receptor; Prostaglandin E2 receptor EP3 subtype; PGE2-R; PGE2 receptor EP3 subtype; PGE receptor, EP3 subtype; PGE receptor EP3 subtype
FUNCTION
The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium. Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality. Receptor for prostaglandin E2 (PGE2).
SEQUENCE
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
DRUGINFO
16,16-dimethyl-PGE2
DRUGINFO
17-phenyl-omega-trinor-PGE2
DRUGINFO
3-(2-((E)-3-phenylprop-1-enyl)phenyl)acrylic acid
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04020 |
|
| hsa04024 |
|
| hsa04080 |
|
| hsa04923 |
|
| hsa05200 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP98 |
|
| WP455 |
|
| WP247 |
|
| WP1825 |
|
| WP1824 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Prostaglandin E2 receptor EP3 (PTGER3) |
|