TARGETID

T85421

FORMERID

TTDR00289

UNIPROID

MK08_HUMAN; MK09_HUMAN; MK10_HUMAN

TARGNAME

Jun N terminal kinase (JNK)

GENENAME

MAPK8; MAPK9; MAPK10

TARGTYPE

Clinical trial target

SYNONYMS

c-Jun N-terminal kinase; Stress-activated protein kinase JNK; SAPK1; PRKM; MAP kinase; JNK

FUNCTION

Associates with scaffold proteins JNK interacting proteins as well as their upstream kinases JNKK1 and JNKK2 following their activation. Modifies the activity of numerous proteins that reside at the mitochondria or act in the nucleus. Downstream molecules that are activated by JNK include c-Jun, ATF2, ELK1, SMAD4, p53 and HSF1. Involved in apoptosis, neurodegeneration, cell differentiation and proliferation, inflammatory conditions and cytokine production mediated by AP-1 (activation protein 1) such as RANTES, IL-8 and GM-CSF.

BIOCLASS

Kinase

SEQUENCE

MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAAGPLGCCR

DRUGINFO

AM-111

DRUGINFO

BGP-15

DRUGINFO

CC-401

DRUGINFO

CC-930

DRUGINFO

PMID25991433-Compound-O1

DRUGINFO

PMID25991433-Compound-Q1

DRUGINFO

2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One