TARGETID

T84117

FORMERID

TTDR00564

UNIPROID

5HT1E_HUMAN

TARGNAME

5-HT 1E receptor (HTR1E)

GENENAME

HTR1E

TARGTYPE

Successful target

SYNONYMS

Serotonin receptor 1E; S31; 5-hydroxytryptamine receptor 1E; 5-HT1E; 5-HT-1E; 5-HT 1E

FUNCTION

Functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. G-protein coupled receptor for 5-hydroxytryptamine (serotonin).

BIOCLASS

GPCR rhodopsin

SEQUENCE

MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT

DRUGINFO

Metergolin

DRUGINFO

[3H]5-HT

DRUGINFO

1-naphthylpiperazine

DRUGINFO

2-(5-fluoro-1H-indol-3-yl)ethanamine

DRUGINFO

2-methyl-5-HT

DRUGINFO

5-BODMT

DRUGINFO

5-CT

DRUGINFO

9-OH-risperidone

DRUGINFO

alpha-methyl-5-HT

DRUGINFO

B173