靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T83875

FORMERID

TTDS00289

UNIPROID

AOFA_HUMAN

TARGNAME

Monoamine oxidase type A (MAO-A)

GENENAME

MAOA

TARGTYPE

Successful target

SYNONYMS

Monoamine oxidase A; Amine oxidase [flavin-containing] A

FUNCTION

MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.

PDBSTRUC

2Z5Y; 2Z5X; 2BXS; 2BXR; 1H8Q

BIOCLASS

CH-NH(2) donor oxidoreductase

ECNUMBER

EC 1.4.3.4

SEQUENCE

MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS

DRUGINFO

Clorgyline

DRUGINFO

Isocarboxazid

DRUGINFO

Moclobemide

DRUGINFO

Tranylcypromine

DRUGINFO

Psoralen

DRUGINFO

TRYPTAMINE

DRUGINFO

CHF-3381

DRUGINFO

CX157

目标的 KEGG 通路数据

标题	内容
hsa00260	Glycine, serine and threonine metabolism
hsa00330	Arginine and proline metabolism
hsa00340	Histidine metabolism
hsa00350	Tyrosine metabolism
hsa00360	Phenylalanine metabolism
hsa00380	Tryptophan metabolism
hsa00982	Drug metabolism - cytochrome P450
hsa01100	Metabolic pathways
hsa04726	Serotonergic synapse
hsa04728	Dopaminergic synapse
hsa05030	Cocaine addiction
hsa05031	Amphetamine addiction
hsa05034	Alcoholism

目标的 Wiki 路径数据

标题	内容
WP706	SIDS Susceptibility Pathways
WP550	Biogenic Amine Synthesis
WP408	Oxidative Stress
WP2436	Dopamine metabolism
WP1879	Phase 1 - Functionalization of compounds
WP1871	Neurotransmitter Release Cycle
WP1870	Neurotransmitter Clearance In The Synaptic Cleft
WP1455	Serotonin Transporter Activity

目标的蛋白质ID

标题	内容
TARGETID	T83875
UNIPROID	AOFA_HUMAN
TARGNAME	Monoamine oxidase type A (MAO-A)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Monoamine oxidase type A (MAO-A)	MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS

标题

内容

Monoamine oxidase type A (MAO-A)

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