TARGETID

T83391

FORMERID

TTDC00152

UNIPROID

F16P1_HUMAN; F16P2_HUMAN

TARGNAME

Fructose-1,6-bisphosphatase (FBP)

GENENAME

FBP1; FBP2

TARGTYPE

Clinical trial target

SYNONYMS

FBPase; D-fructose-1,6-bisphosphate 1-phosphohydrolase

FUNCTION

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

BIOCLASS

Phosphoric monoester hydrolase

SEQUENCE

MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ

DRUGINFO

Managlinat dialanetil

DRUGINFO

MB07803

DRUGINFO

1-(2-mercaptoethyl)-3-(m-tolylsulfonyl)urea

DRUGINFO

1-(4-aminophenylsulfonyl)-3-(2-mercaptoethyl)urea

DRUGINFO

2-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol

DRUGINFO

2,5-Anhydroglucitol-1,6-Biphosphate

DRUGINFO

3-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol

DRUGINFO

4-(2-amino-1,3-thiazol-4-yl)phenol

DRUGINFO

4-(4-(4-Nitrophenyl)thiazol-2-ylamino)phenol

DRUGINFO

4,6-Dichloro-1H-indole-2-carboxylic acid