靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T82841

FORMERID

TTDNC00576

UNIPROID

INS_HUMAN

TARGNAME

Insulin (INS)

GENENAME

INS

TARGTYPE

Successful target

SYNONYMS

Insulin

FUNCTION

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

PDBSTRUC

6HN5; 6CK2; 6CEB; 6CE9; 6CE7

SEQUENCE

MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

DRUGINFO

Insulin degludec

DRUGINFO

Insulin determir

DRUGINFO

Insulin Susp Isophane Recombinant Human

Approved

DRUGINFO

D0I1PY

Insulin Susp Protamine Zinc Beef/Pork

Approved

DRUGINFO

D03FIL

Insulin Zinc Susp Recombinant Human

DRUGINFO

Insulin-aspart

DRUGINFO

Insulin-detemir

DRUGINFO

Insulin-glargine

DRUGINFO

Inulin

DRUGINFO

LY2605541

目标的 KEGG 通路数据

标题	内容
hsa04014	Ras signaling pathway
hsa04015	Rap1 signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04066	HIF-1 signaling pathway
hsa04068	FoxO signaling pathway
hsa04114	Oocyte meiosis
hsa04140	Regulation of autophagy
hsa04150	mTOR signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04152	AMPK signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa04910	Insulin signaling pathway
hsa04911	Insulin secretion
hsa04913	Ovarian steroidogenesis
hsa04914	Progesterone-mediated oocyte maturation
hsa04917	Prolactin signaling pathway
hsa04930	Type II diabetes mellitus
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa04940	Type I diabetes mellitus
hsa04950	Maturity onset diabetes of the young
hsa04960	Aldosterone-regulated sodium reabsorption
hsa05215	Prostate cancer

目标的 Wiki 路径数据

标题	内容
WP615	Senescence and Autophagy in Cancer
WP2848	Differentiation Pathway
WP2736	Insulin Processing
WP2509	Nanoparticle triggered autophagic cell death
WP2406	Cardiac Progenitor Differentiation
WP236	Adipogenesis
WP2324	AGE/RAGE pathway
WP1982	SREBP signalling
WP1946	Cori Cycle
WP1926	Synthesis, Secretion, and Deacylation of Ghrelin
WP1913	Signaling by Insulin receptor
WP1897	Regulation of beta-cell development
WP1831	Integration of energy metabolism
WP176	Folate Metabolism
WP1533	Vitamin B12 Metabolism
WP15	Selenium Micronutrient Network

目标的蛋白质ID

标题	内容
TARGETID	T82841
UNIPROID	INS_HUMAN
TARGNAME	Insulin (INS)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Insulin (INS)	MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

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