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靶点信息54(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Neuronal acetylcholine receptor beta-2 (CHRNB2)
TARGTYPE
Clinical trial target
SYNONYMS
Nicotinic acetylcholine receptor beta2; Nicotinic acetylcholine receptor beta 2-subunit protein; CHRNB2; Beta-2 nAChR; Alpha-4/beta-2 nicotinic receptor
FUNCTION
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
PDBSTRUC
6CNK; 6CNJ; 5KXI; 2LM2; 2KSR
BIOCLASS
Neurotransmitter receptor
SEQUENCE
MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK
DRUGINFO
(2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol
DRUGINFO
(2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04080 |
|
| hsa04725 |
|
| hsa05033 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Neuronal acetylcholine receptor beta-2 (CHRNB2) |
|