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靶点信息18(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Cancer/testis antigen 1 (NY-ESO-1)
TARGTYPE
Clinical trial target
SYNONYMS
LAGE2B; LAGE2A; LAGE2; LAGE-2; L antigen family member 2; ESO1; Cancer/testis antigen 6.1; CTAG1B; CTAG1; CTAG; CT6.1; Autoimmunogenic cancer/testis antigen NYESO1; Autoimmunogenic cancer/testis antigen NY-ESO-1
FUNCTION
Immunogenic protein. Its aberrant re-expression is induced by molecular mechanisms including: DNA demethylation, histone post-translational modification, and microRNA-mediated regulation. The effect of DNA demethylation is evident by the capability of demethylating agents, like 5-aza-2-deoxycytidine, to induce the re-expression of NY-ESO-1 in tumour cells but not in normal epithelial cells.
PDBSTRUC
6AVG; 6AVF; 6AT5; 3KLA; 3HAE
SEQUENCE
MQAEGRGTGGSTGDADGPGGPGIPDGPGGNAGGPGEAGATGGRGPRGAGAARASGPGGGAPRGPHGGAASGLNGCCRCGARGPESRLLEFYLAMPFATPMEAELARRSLAQDAPPLPVPGVLLKEFTVSGNILTIRLTAADHRQLQLSISSCLQQLSLLMWITQCFLPVFLAQPPSGQRR
DRUGINFO
Anti-NY-ESO-1 CAR-T cells
DRUGINFO
NY-ESO-1 vaccine
DRUGINFO
Melanoma vaccine (ALVAC)
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Cancer/testis antigen 1 (NY-ESO-1) |
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