TARGETID

T82146

FORMERID

TTDS00075

UNIPROID

RARG_HUMAN

TARGNAME

Retinoic acid receptor gamma (RARG)

GENENAME

RARG

TARGTYPE

Successful target

SYNONYMS

RAR-gamma; Nuclear receptor subfamily 1 group B member 3; NR1B3

FUNCTION

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

PDBSTRUC

6FX0; 5M24; 4LBD; 3LBD; 2LBD

BIOCLASS

Nuclear hormone receptor

SEQUENCE

MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA

DRUGINFO

Alitretinoin

DRUGINFO

Tazarotene

DRUGINFO

Tretinoin

DRUGINFO

Trifarotene

DRUGINFO

Palovarotene

DRUGINFO

PMID27336223-Compound-11

DRUGINFO

PMID27336223-Compound-12

DRUGINFO

PMID27336223-Compound-13

DRUGINFO

PMID27336223-Compound-14