靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T82028

FORMERID

TTDR00347

UNIPROID

SL9A1_HUMAN

TARGNAME

Sodium/hydrogen exchanger 1 (SLC9A1)

GENENAME

SLC9A1

TARGTYPE

Clinical trial target

SYNONYMS

Solute carrier family 9 member 1; Na+/H+ antiporter, amiloride-sensitive; Na(+)Sodium/hydrogen exchanger 1/H(+) exchanger 1; Na(+)/H(+) exchanger 1; Na(+)/H(+) antiporter, amiloride-sensitive; NHE1; NHE-1; Myocardial Na+/H+ exchanger; APNH1; APNH

FUNCTION

Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions.

PDBSTRUC

6BJF; 2YGG; 2MDF; 2L0E; 2KBV

BIOCLASS

Monovalent cation:proton antiporter-1

SEQUENCE

MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ

DRUGINFO

D0C8PI

Zoniporide hydrochloride

Phase 3

DRUGINFO

D0N8QQ

CARIPORIDE

Discontinued in Phase 2

DRUGINFO

D0V9RU

ENIPORIDE

Discontinued in Phase 2

DRUGINFO

D0K2CV

HOE-694

Terminated

DRUGINFO

D0V5NZ

5'-(N-ethyl-N-isopropyl)amiloride

DRUGINFO

BIIB-513

DRUGINFO

Homoserine Lactone

DRUGINFO

N-(3-Methanesulfonyl-4-methoxy-benzoyl)-guanidine

Investigative

DRUGINFO

D03AGV

N-(3-Methanesulfonyl-4-methyl-benzoyl)-guanidine

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04024	cAMP signaling pathway
hsa04260	Cardiac muscle contraction
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04810	Regulation of actin cytoskeleton
hsa04919	Thyroid hormone signaling pathway
hsa04970	Salivary secretion
hsa04971	Gastric acid secretion
hsa04972	Pancreatic secretion
hsa04976	Bile secretion
hsa05205	Proteoglycans in cancer

目标的 Wiki 路径数据

标题	内容
WP51	Regulation of Actin Cytoskeleton
WP35	G Protein Signaling Pathways
WP2743	Glycosaminoglycan metabolism
WP12	Osteoclast Signaling

目标的蛋白质ID

标题	内容
TARGETID	T82028
UNIPROID	SL9A1_HUMAN
TARGNAME	Sodium/hydrogen exchanger 1 (SLC9A1)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Sodium/hydrogen exchanger 1 (SLC9A1)	MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ

标题

内容

Sodium/hydrogen exchanger 1 (SLC9A1)

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