靶点信息21(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Kruppel like factor 4 (KLF4)
TARGTYPE
Clinical trial target
SYNONYMS
Krueppellike factor 4; Krueppel-like factor 4; Gutenriched krueppellike factor; Gut-enriched krueppel-like factor; GKLF; Epithelial zinc finger protein EZF; EZF
FUNCTION
Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. Transcription factor; can act both as activator and as repressor.
SEQUENCE
MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPGRPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESVAATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQVPPLHYQGQSRGFVARAGEPCVCWPHFGTHGMMLTPPSSPLELMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF
KEGGPATH
hsa04550:Signaling pathways regulating pluripotency of stem cells
WIKIPATH
WP1926:Synthesis, Secretion, and Deacylation of Ghrelin
WIKIPATH
WP1991:SRF and miRs in Smooth Muscle Differentiation and Proliferation
WIKIPATH
WP2023:Cell Differentiation - meta
WIKIPATH
WP2751:Transcriptional Regulation of White Adipocyte Differentiation
WIKIPATH
WP2821:Transcriptional regulation of pluripotent stem cells
WIKIPATH
WP2857:Mesodermal Commitment Pathway
WIKIPATH
WP2877:Vitamin D Receptor Pathway
REACPATH
R-HSA-381340:Transcriptional regulation of white adipocyte differentiation
REACPATH
R-HSA-452723:Transcriptional regulation of pluripotent stem cells
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP2877 |
|
| WP2857 |
|
| WP2821 |
|
| WP2751 |
|
| WP2023 |
|
| WP1991 |
|
| WP1926 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Kruppel like factor 4 (KLF4) |
|