靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T81311

FORMERID

TTDI01987

UNIPROID

ENPL_HUMAN

TARGNAME

Endoplasmin (HSP90B1)

GENENAME

HSP90B1

TARGTYPE

Clinical trial target

SYNONYMS

gp96 homolog; Tumor rejection antigen 1; TRA1; Heat shock protein 90 kDa beta member 1; GRP94; GRP-94; 94 kDa glucoseregulated protein; 94 kDa glucose-regulated protein

FUNCTION

When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Molecular chaperone that functions in the processing and transport of secreted proteins.

PDBSTRUC

4NH9

BIOCLASS

Heat shock protein

SEQUENCE

MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL

DRUGINFO

D0F3EO

HS-110

Phase 2

KEGGPATH

hsa04141:Protein processing in endoplasmic reticulum

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04621:NOD-like receptor signaling pathway

KEGGPATH

hsa04915:Estrogen signaling pathway

KEGGPATH

hsa04918:Thyroid hormone synthesis

KEGGPATH

hsa05200:Pathways in cancer

KEGGPATH

hsa05215:Prostate cancer

WIKIPATH

WP2655:Activation of Chaperone Genes by ATF6-alpha

目标的 KEGG 通路数据

标题	内容
hsa04141	Protein processing in endoplasmic reticulum
hsa04151	PI3K-Akt signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04915	Estrogen signaling pathway
hsa04918	Thyroid hormone synthesis
hsa05200	Pathways in cancer
hsa05215	Prostate cancer

目标的 Wiki 路径数据

标题	内容
WP706	SIDS Susceptibility Pathways
WP2784	Binding and Uptake of Ligands by Scavenger Receptors
WP2709	Trafficking and processing of endosomal TLR
WP2655	Activation of Chaperone Genes by ATF6-alpha

目标的蛋白质ID

标题	内容
TARGETID	T81311
UNIPROID	ENPL_HUMAN
TARGNAME	Endoplasmin (HSP90B1)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Endoplasmin (HSP90B1)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL

标题

内容

Endoplasmin (HSP90B1)

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