当前位置：药药网 / 数据中心 /靶点信息(本栏目收费,不能显示细节,电话13136136841)
靶点信息23(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Caspase 2 messenger RNA (CASP2 mRNA)
TARGTYPE
Clinical trial target
SYNONYMS
Protease ICH1 (mRNA); Protease ICH-1 (mRNA); Neural precursor cell expressed developmentally downregulated protein 2 (mRNA); Neural precursor cell expressed developmentally down-regulated protein 2 (mRNA); NEDD2 (mRNA); NEDD-2 (mRNA); ICH1 (mRNA); Caspase2 subunit p12 (mRNA); CASP-2 (mRNA)
FUNCTION
Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress. Involved in the activation cascade of caspases responsible for apoptosis execution.
SEQUENCE
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
WIKIPATH
WP1772:Apoptosis Modulation and Signaling
WIKIPATH
WP1976:Signalling by NGF
WIKIPATH
WP2371:Parkinsons Disease Pathway
WIKIPATH
WP384:Apoptosis Modulation by HSP70
REACPATH
R-HSA-168638:NOD1/2 Signaling Pathway
REACPATH
R-HSA-205025:NADE modulates death signalling
NET_PATH
NetPath_11:TCR Signaling Pathway
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP2371 |
|
| WP1976 |
|
| WP1772 |
|
| WP384 |
|
| WP254 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Caspase 2 messenger RNA (CASP2 mRNA) |
|