靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T77796

FORMERID

TTDR01197

UNIPROID

TRFR_HUMAN

TARGNAME

Thyrotropin-releasing hormone receptor (TRHR)

GENENAME

TRHR

TARGTYPE

Successful target

SYNONYMS

Thyroliberin receptor; TRH-R

FUNCTION

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS

DRUGINFO

protirelin

DRUGINFO

AZETIRELIN

DRUGINFO

MONTIRELIN TETRAHYDRATE

Discontinued in Preregistration

DRUGINFO

D0J8RM

Posatirelin

Discontinued in Phase 3

DRUGINFO

D03BHO

JTP-2942

Discontinued in Phase 2

DRUGINFO

C4X-101

DRUGINFO

CORYMBONE B

DRUGINFO

MeTRH

DRUGINFO

MK-771

KEGGPATH

hsa04020:Calcium signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction

目标的 Wiki 路径数据

标题	内容
WP455	GPCRs, Class A Rhodopsin-like
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP24	Peptide GPCRs
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling

目标的蛋白质ID

标题	内容
TARGETID	T77796
UNIPROID	TRFR_HUMAN
TARGNAME	Thyrotropin-releasing hormone receptor (TRHR)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Thyrotropin-releasing hormone receptor (TRHR)	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS

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