靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T77365

FORMERID

TTDS00187

UNIPROID

AA2AR_HUMAN

TARGNAME

Adenosine A2a receptor (ADORA2A)

GENENAME

ADORA2A

TARGTYPE

Successful target

SYNONYMS

Adenosine receptor A2a; ADORA2; A2a Adenosine receptor; A(2A) adenosine receptor

FUNCTION

The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Receptor for adenosine.

PDBSTRUC

6MH8; 6GDG; 6AQF; 5WF6; 5WF5

BIOCLASS

GPCR rhodopsin

SEQUENCE

MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS

DRUGINFO

Caffeine

DRUGINFO

Istradefylline

DRUGINFO

Regadenoson

DRUGINFO

Apadenoson

DRUGINFO

Binodenoson

DRUGINFO

Tozadenant

DRUGINFO

AMP-579

DRUGINFO

AZD4635

DRUGINFO

BIIB014

目标的 KEGG 通路数据

标题	内容
hsa04015	Rap1 signaling pathway
hsa04020	Calcium signaling pathway
hsa04024	cAMP signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04270	Vascular smooth muscle contraction
hsa05012	Parkinson's disease
hsa05034	Alcoholism

目标的 Wiki 路径数据

标题	内容
WP80	Nucleotide GPCRs
WP727	Monoamine Transport
WP455	GPCRs, Class A Rhodopsin-like
WP1873	NGF signalling via TRKA from the plasma membrane
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling
WP117	GPCRs, Other

目标的蛋白质ID

标题	内容
TARGETID	T77365
UNIPROID	AA2AR_HUMAN
TARGNAME	Adenosine A2a receptor (ADORA2A)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Adenosine A2a receptor (ADORA2A)	MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS

标题

内容

Adenosine A2a receptor (ADORA2A)

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