靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T74977

FORMERID

TTDR01110

UNIPROID

TTK_HUMAN

TARGNAME

Dual specificity protein kinase TTK (MPS1)

GENENAME

TTK

TARGTYPE

Clinical trial target

SYNONYMS

Tyrosine threonine kinase; Phosphotyrosine picked threonine-protein kinase; PYT; MPS1L1

FUNCTION

Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. Phosphorylates proteins on serine, threonine, and tyrosine.

PDBSTRUC

6N6O; 6H3K; 6GVJ; 6B4W; 5O91

BIOCLASS

Kinase

ECNUMBER

EC 2.7.12.1

SEQUENCE

MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK

DRUGINFO

BAY1161909

DRUGINFO

BOS172722

DRUGINFO

CFI-402257

DRUGINFO

Tricyclic isoxazoloquinazoline derivative 2

Patented

DRUGINFO

D0WK2S

Tricyclic isoxazoloquinazoline derivative 3

Patented

DRUGINFO

D0JC8E

Tricyclic isoxazoloquinazoline derivative 4

Patented

DRUGINFO

D02PVB

2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One

Investigative

DRUGINFO

D0J5FK

GNE-7915

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04110	Cell cycle

目标的 Wiki 路径数据

标题	内容
WP2446	Retinoblastoma (RB) in Cancer

目标的蛋白质ID

标题	内容
TARGETID	T74977
UNIPROID	TTK_HUMAN
TARGNAME	Dual specificity protein kinase TTK (MPS1)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Dual specificity protein kinase TTK (MPS1)	MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK

标题

内容

Dual specificity protein kinase TTK (MPS1)

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