靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T63484

FORMERID

TTDR00008

UNIPROID

G6PD_HUMAN

TARGNAME

Glucose-6-phosphate dehydrogenase (G6PD)

GENENAME

G6PD

TARGTYPE

Successful target

SYNONYMS

Glucose-6-phosphate 1-dehydrogenase

FUNCTION

The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

PDBSTRUC

6.00E+08; 6.00E+07; 5UKW; 2BHL; 2BH9

BIOCLASS

CH-OH donor oxidoreductase

ECNUMBER

EC 1.1.1.49

SEQUENCE

MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL

DRUGINFO

Prasterone

DRUGINFO

EPIANDROSTERONE

DRUGINFO

CBF-BS2

Discontinued in Phase 2

DRUGINFO

D0J2FY

2'-Monophosphoadenosine 5'-Diphosphoribose

DRUGINFO

Hydroxyacetic Acid

DRUGINFO

Metazamide

KEGGPATH

hsa00030:Pentose phosphate pathway

KEGGPATH

hsa00480:Glutathione metabolism

目标的 KEGG 通路数据

标题	内容
hsa01200	Carbon metabolism
hsa05230	Central carbon metabolism in cancer
hsa00030	Pentose phosphate pathway
hsa00480	Glutathione metabolism
hsa01100	Metabolic pathways
hsa01130	Biosynthesis of antibiotics

目标的 Wiki 路径数据

标题	内容
WP692	Sulfation Biotransformation Reaction
WP2884	NRF2 pathway
WP2882	Nuclear Receptors Meta-Pathway
WP2877	Vitamin D Receptor Pathway
WP2005	miR-targeted genes in muscle cell - TarBase
WP2004	miR-targeted genes in lymphocytes - TarBase
WP2003	miR-targeted genes in leukocytes - TarBase
WP2002	miR-targeted genes in epithelium - TarBase
WP1946	Cori Cycle
WP1848	Metabolism of carbohydrates
WP134	Pentose Phosphate Pathway
WP100	Glutathione metabolism

目标的蛋白质ID

标题	内容
TARGETID	T63484
UNIPROID	G6PD_HUMAN
TARGNAME	Glucose-6-phosphate dehydrogenase (G6PD)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Glucose-6-phosphate dehydrogenase (G6PD)	MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL

标题

内容

Glucose-6-phosphate dehydrogenase (G6PD)

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